abstract：CONTEXT:COVID-19 is a novel coronavirus that causes a severe infection in the respiratory system. Nigella sativa L. (Ranunculaceae) is an annual flowering plant used traditionally as a natural food supplement and multipurpose medicinal agent. OBJECTIVE:The possible beneficial effects of N. sativa, and its constituent,...

authors： Khazdair MR,Ghafari S,Sadeghi M

更新日期：2021-12-01 00:00:00

abstract：:Voltage-gated calcium channels (VGCCs) represent key regulators of the calcium influx through the plasma membrane of excitable cells, like neurons. Activated by the depolarization of the membrane, the opening of VGCCs induces very transient and local changes in the intracellular calcium concentration, known as calcium...

authors： Heck J,Palmeira Do Amaral AC,Weißbach S,El Khallouqi A,Bikbaev A,Heine M

更新日期：2021-12-01 00:00:00

abstract：:Japanese encephalitis virus (JEV), a member of the Flavivirus genus, is an important pathogen that causes human and animal infectious diseases in Asia. So far, no effective antiviral agents are available to treat JEV infection. Here, we found that LDLR is a host factor required for JEV entry. Berbamine significantly d...

authors： Huang L,Li H,Ye Z,Xu Q,Fu Q,Sun W,Qi W,Yue J

更新日期：2021-12-01 00:00:00

abstract：:Fluoxetine is used to improve cognition, exercise ability, depression, and neurological functions in patients with cerebral ischemic stroke. Circular RNAs (circRNAs) play important regulatory roles in multiple diseases. However, studies regarding the fluoxetine-mediated circRNA-microRNA-messenger RNA (mRNA) axis have ...

authors： He Y,Zhang H,Deng J,Cai Z,Gu M,Zhao C,Guo Y

更新日期：2021-12-01 00:00:00

abstract：:ABSTRACTThe two main Zika virus (ZIKV) vectors, Aedes albopictus and Aedes aegypti (invasive and native species, respectively), are present in Gabon (Central Africa). The aim of this study was to determine the entomological ZIKV risk associated with these mosquito species in Gabon by evaluating their vector competence...

authors： Jiolle D,Moltini-Conclois I,Obame-Nkoghe J,Yangari P,Porciani A,Scheid B,Kengne P,Ayala D,Failloux AB,Paupy C

更新日期：2021-12-01 00:00:00

abstract：:Objectives: Hypertension is thought to be a contributor to mortality in coronavirus disease 2019 patients; however, limited clinical data on the outcomes of COVID-19 in patients with hypertension are available.Methods: This study was designed to confirm whether hypertension affects the outcomes of COVID-19. Results: A...

authors： Zhong L,Wu Y,Gao J,Zhang J,Xie Q,He H,Ji J,Liu Z,Wang C,Liu Z

更新日期：2021-12-01 00:00:00

abstract：:Streptococcus suis (S. suis) is an important rising pathogen that causes serious diseases in humans and pigs. Although some putative virulence factors of S. suis have been identified, its pathogenic mechanisms are largely unclear. Here, we identified a putative virulence-associated factor MutT, which is unique to S. s...

authors： Li Q,Fei X,Zhang Y,Guo G,Shi H,Zhang W

更新日期：2021-12-01 00:00:00

abstract：:The main aim of this work was to evaluate differential expression and biological functions of circulating miRNA and whole peripheral blood (PB) genes in patients affected by venous thromboembolism (VTE) and in healthy subjects. Circulating miRNA sequences and PB expression profiles were obtained from GEO datasets. Ten...

authors： Chen X,Cao J,Ge Z,Xia Z

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Co-administration between warfarin (WF) and Curcuma xanthorrhiza Roxb. (Zingiberaceae) (CX) is found in Indonesian patients and need to be evaluated. OBJECTIVE:This study assesses the effect of concomitant administration of CX extract on the pharmacokinetics of WF in rats. MATERIALS AND METHODS:Wistar rats we...

authors： Rusdiana T,Mardhiani YD,Putriana NA,Gozali D,Nagano D,Araki T,Yamamoto K

更新日期：2021-12-01 00:00:00

abstract：:Etuaptmumk or Two-Eyed Seeing (E/TES) is foundational in ensuring that Indigenous ways of knowing are respected, honoured, and acknowledged in health research practices with Indigenous Peoples of Canada. This paper will outline new knowledge gleaned from the Canadian Institute of Health Research and Chronic Pain Netwo...

authors： Sylliboy JR,Latimer M,Marshall EA,MacLeod E

更新日期：2021-12-01 00:00:00

abstract：:NOD1 is an intracellular receptor that, when activated, induces gene expression of pro-inflammatory factors promoting macrophages and neutrophils recruitment at the infection site. However, iE-DAP, the dipeptide agonist that promotes this receptor's activation, cannot permeate cell membranes. To develop a nanocarrier ...

authors： Cabaña-Brunod M,Herrera PA,Márquez-Miranda V,Llancalahuen FM,Duarte Y,González-Nilo D,Fuentes JA,Vilos C,Velásquez L,Otero C

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:S-propargyl-cysteine (SPRC), an excellent endogenous hydrogen sulfide (H2S) donor, could elevate H2S levels via the cystathionine γ-lyase (CSE)/H2S pathway both in vitro and in vivo. However, the immediate release of H2S in vivo and daily administration of SPRC potentially limited its clinical use. METHODS:To ...

authors： Yu Y,Wang Z,Yang Q,Ding Q,Wang R,Li Z,Fang Y,Liao J,Qi W,Chen K,Li M,Zhu YZ

更新日期：2021-12-01 00:00:00

abstract：:The ongoing pandemic of COVID-19, caused by SARS-CoV-2, has severely impacted the global public health and socio-economic stability, calling for effective vaccines and therapeutics. In this study, we continued our efforts to develop more efficient SARS-CoV-2 fusion inhibitors and achieved significant findings. First, ...

authors： Yu D,Zhu Y,Jiao T,Wu T,Xiao X,Qin B,Chong H,Lei X,Ren L,Cui S,Wang J,He Y

更新日期：2021-12-01 00:00:00

abstract：:Although human/eukaryotic ribosomal protein L14 (RPL14/eL14) is known to be associated with a variety of cancers, its role in nasopharyngeal carcinoma (NPC) remains unclear. The aim of this study was to explore the impact of RPL14(eL14) in NPC. The results of quantitative real-time polymerase chain reaction (qRT-PCR),...

authors： Zhang Z,Zhang Y,Qiu Y,Mo W,Yang Z

更新日期：2021-12-01 00:00:00

abstract：:The biological modulatory roles of many circular RNAs (circRNAs) have been validated in glioma. The current study was designed to research the functional mechanism of circ_0001162 in glioma progression. The quantitative real-time polymerase chain reaction (qRT-PCR) was used for assaying the levels of circ_0001162 and ...

authors： Zhou D,Lin X,Wang P,Yang Y,Zheng J,Zhou D

更新日期：2021-12-01 00:00:00

abstract：:Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation. A new generation of CA inhibitors, AN11-740 and AN6-277 and the refer...

authors： Dettori I,Fusco I,Bulli I,Gaviano L,Coppi E,Cherchi F,Venturini M,Di Cesare Mannelli L,Ghelardini C,Nocentini A,Supuran CT,Pugliese AM,Pedata F

更新日期：2021-12-01 00:00:00

abstract：:ABSTRACTSeveral nairo-like viruses have been discovered in ticks in recent years, but their relevance to public health remains unknown. Here, we found a patient who had a history of tick bite and suffered from a febrile illness was infected with a previously discovered RNA virus, Beiji nairovirus (BJNV), in the nairo-...

authors： Wang YC,Wei Z,Lv X,Han S,Wang Z,Fan C,Zhang X,Shao J,Zhao YH,Sui L,Chen C,Liao M,Wang B,Jin N,Li C,Ma J,Hou ZJ,Yang Z,Han Z,Zhang Y,Niu J,Wang W,Wang Y,Liu Q

更新日期：2021-12-01 00:00:00

abstract：:Osteoporosis poses a threat to human health worldwide. To date, there have been few studies regarding targeted treatment of osteoporosis. We aimed to identify the possible molecular mechanism of circular RNA (circ)_0062582 in osteogenic differentiation, and the interactions among circ_0062582, microRNA-145 (miR-145) a...

authors： Li F,Wu H,Zou G,Cang D,Shen Y

更新日期：2021-12-01 00:00:00

abstract：:Background: The Mediterranean diet (MedDiet) is a dietary pattern effective in terms of prevention of many diseases such as gestational diabetes mellitus (GDM). Recently, many studies have paid attention to nutritional factors during pregnancy as a modifiable contributor to GDM risk.Objective: to investigate associati...

authors： Mahjoub F,Ben Jemaa H,Ben Sabeh F,Ben Amor N,Gamoudi A,Jamoussi H

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumour cell growth by inducing cell cycle arrest. However, its underlying anticancer mechanism remains unclear. OBJECTIVE:The effects of LAF on the Hippo-Yes-associated protein (YAP) signalling pathway, which plays an important r...

authors： Li X,Lin YY,Tan JY,Liu KL,Shen XL,Hu YJ,Yang RY

更新日期：2021-12-01 00:00:00

abstract：:High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, can be released into extracellular space and function as a strong proinflammatory cytokine, which plays critical roles in the pathogenesis of various inflammatory diseases. Here, we showed that BoHV-1 productive infection in MDBK cells at later stage...

authors： Fan W,Yuan W,Ding X,Zhu L

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Visfatin is considered to be a biomarker in various types of cancers, including colon cancer. Moreover, evidence for epigenetic mechanism must be reported for an association between visfatin level and colon cancer. Therefore, this study was designed to investigate the status of visfatin expression and the gl...

authors： Al Abdulsalam EA,Al Harithy RN

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) is characterized by severe local and systemic inflammation. Ac2-26, an Annexin A1 Peptide, can reduce the lung injury induced by reperfusion via the inhibition of inflammation. The present study aims to evaluate the effect and mechanism of Ac2-26 in ARDS. METHODS:T...

authors： Ju Y,Qiu L,Sun X,Liu H,Gao W

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the efficiency of prostate-specific antigen (PSA) density (PSAD) calculated through prostate volume (PV) obtained via transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI) and actual prostate weight (PW) methods obtained via pathological evaluation on the pr...

authors： Danacioglu YO,Keser F,Efiloğlu Ö,Culpan M,Polat S,Atis RG,Yildirim A

更新日期：2021-12-01 00:00:00

abstract：:The non-nucleoside reverse transcriptase inhibitor VM1500A is approved for the treatment of HIV/AIDS in its N-acyl sulphonamide prodrug form elsulfavirine (Elpida®). Biochemical profiling against twelve human carbonic anhydrase (CA, EC 4.2.1.1) isoforms showed that while elsulfavirine was a weak inhibitor of all isofo...

authors： Supuran CT,Nocentini A,Yakubova E,Savchuk N,Kalinin S,Krasavin M

更新日期：2021-12-01 00:00:00

abstract：:Purpose: Long-term pain is a public health problem but few studies have focused on experiences among women with CWP. This study aimed to explore women's experiences of the impact of CWP on daily life.Method: The participants were 19 women between 45-67 years old, who had developed CWP between 1995 and 2016. Individual...

authors： Westergården M,Aili K,Larsson I

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Hepatic encephalopathy (HE) is a complex neuropsychiatric disease caused by liver failure. Dihydromyricetin (DMY) is a traditional medicine used to treat liver injury. OBJECTIVE:To investigate the effects of dihydromyricetin (DMY) on hepatic encephalopathy associated with acute hepatic failure mice models esta...

authors： Cheng L,Wang X,Ma X,Xu H,Yang Y,Zhang D

更新日期：2021-12-01 00:00:00

abstract：:Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells. Human neutrophil elastase is known to play multiple roles in the human body, but an increase in its activity may cause a variety of diseases. Elastase inhibitors may prev...

authors： Jakimiuk K,Gesek J,Atanasov AG,Tomczyk M

更新日期：2021-12-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play vital roles in the progression of hypertrophic scar (HS). We aimed to explore the effect of lncRNA INHBA Antisense RNA1 (INHBA-AS1) in the formation of HS and identify the potential mechanisms. INHBA-AS1 and microRNA (miR)-141-3p expression in human HS fibroblasts (hHSFs) was determi...

authors： Yang Y,Xiao C,Liu K,Song L,Zhang Y,Dong B

更新日期：2021-12-01 00:00:00

abstract：:The mechanosensitive channel Piezo1 is a crucial membrane mechanosensor ubiquitously expressed in mammalian cell types. Critical to its function in mechanosensory transduction is its ability to change conformation in response to applied mechanical force. Here, we interrogate the role of the anchor domain in the mechan...

authors： Vero Li J,D Cox C,Martinac B

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China. METHODS:We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin Univers...

authors： Nie P,Lou Y,Wang Y,Bai X,Zhang L,Jiang S,Li B,Luo P

更新日期：2021-12-01 00:00:00

abstract：:Mastitis (intramammary inflammation) caused by infectious pathogens is still considered a devastating condition of dairy animals affecting animal welfare as well as economically incurring huge losses to the dairy industry by means of decreased production performance and increased culling rates. Bovine mastitis is the ...

authors： Sharun K,Dhama K,Tiwari R,Gugjoo MB,Iqbal Yatoo M,Patel SK,Pathak M,Karthik K,Khurana SK,Singh R,Puvvala B,Amarpal,Singh R,Singh KP,Chaicumpa W

更新日期：2021-12-01 00:00:00

abstract：:To date, only low pathogenic (LP) H5 and H7 avian influenza viruses (AIV) have been observed to naturally shift to a highly pathogenic (HP) phenotype after mutation of the monobasic hemagglutinin (HA) cleavage site (HACS) to polybasic motifs. The LPAIV monobasic HACS is activated by tissue-restricted trypsin-like enzy...

authors： Gischke M,Bagato O,Breithaupt A,Scheibner D,Blaurock C,Vallbracht M,Karger A,Crossley B,Veits J,Böttcher-Friebertshäuser E,Mettenleiter TC,Abdelwhab EM

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Kaempferol, a flavonoid glycoside, has many hepatoprotective effects in several animals due to its antioxidant potential. OBJECTIVE:This study evaluated the hepatoprotective effect of kaempferol against acetaminophen (APAP)-induced liver damage and examined whether the protection involved modulation of silent ...

authors： BinMowyna MN,AlFaris NA

更新日期：2021-12-01 00:00:00

abstract：:Feijoa sellowiana leaves and fruits have been investigated as a source of diverse bioactive metabolites. Extract and eight metabolites isolated from F. sellowiana leaves were evaluated for their enzymatic inhibitory activity against α-glucosidase, amylase, tyrosinase, acetylcholinestrerase and butyrylcholinesterase bo...

authors： Saber FR,Ashour RM,El-Halawany AM,Mahomoodally MF,Ak G,Zengin G,Mahrous EA

更新日期：2021-12-01 00:00:00

abstract：:The HIV/AIDS prevalence in female sex workers (FSWs) and elderly male clients is increasing in Guangxi, China, but the transmission relationship between them remains unclear. This study aims to illuminate the transmission network between FSWs and elderly male clients using molecular epidemiological analyses. Phylogene...

authors： Chen X,Qin C,Chen R,Huang Y,Xu Y,Tang Q,Liang X,Peng B,Shao Y,Yang Y,Chen J,Wang X,Wen L,Liang B,Ye L,Qin X,Jiang J,Liang H

更新日期：2021-12-01 00:00:00

abstract：:Fatty acid desaturase 1 (FADS1) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between FADS1 variants and SAT inflammatory status. To advance this area, we conducted an exploratory study to investigate whether...

authors： Wang C,Murphy J,Delaney KZ,Khor N,Morais JA,Tsoukas MA,Lowry DE,Mutch DM,Santosa S

更新日期：2021-12-01 00:00:00

abstract：:To investigate the release strategies of sterile mosquitoes for the wild population control, we propose mathematical models for the interaction between two-mosquito populations incorporating impulsive releases of sterile ones. The long-term control model is first studied, and the existence and stability of the wild mo...

authors： Huang M,You L,Liu S,Song X

更新日期：2021-12-01 00:00:00

abstract：:To explore the research status, hotspots, and trends in research on nicotinic acetylcholine receptor (nAChR) channel. The Web of Science core collection database from 2000 to 2020 was used as the data source. The visual analysis software VOSviewer1.6.16 and Citespace5.7 R3 were used to visualize the studies of the nAC...

authors： Zhu X,Zhou Y,Yuan G,Shi J,Shi S,Zhang L,Chai R,Du Y,Duan C,Hu Y

更新日期：2021-12-01 00:00:00

abstract：:Growing evidences suggest that autophagy plays a momentous part in the tumorigenesis and development of hepatocellular carcinoma (HCC). However, there are not many researches to predict the prognosis of HCC using autophagy-related genes. Therefore, based on the clinical information and RNA-Seq data of The Cancer Genom...

authors： Cao J,Wu L,Lei X,Shi K,Shi L

更新日期：2021-12-01 00:00:00